Actively Recruiting Prostate Cancer Clinical Trials Summary
By Class of Drug


Non-Steroidal Anti Androgens

These drugs work by preventing the active form of testosterone (also known as DHT) from stimulating the prostate and prostate cancer cells to grow. 
 

Study Name

Drug

Sponsor

Phase

Clinical Trials Link

PHEN Link

PANTHER

apalutamide (Erleada ) & abiraterone acetate (Zytiga)

Janssen Scientific

2

Clinicaltrials.gov

-

CYPIDES

ODM-208

Orion Pharma

2

Clinicaltrials.gov

-

PROTEUS

apalutamide (Erleada)

Janssen

3

Clinicaltrials.gov

PHEN Information

 


GNRH Antagonist

This class of drugs prevents the release of certain hormones that stimulate testosterone production in the body. The decrease in testosterone production leads to less prostate and prostate cancer cell stimulation. 

Study Name

Drug

Sponsor

Phase

Clinical Trials Link

PHEN Link

HERO

relugolix

Myovant Sciences GmbH

3

Clinicaltrials.gov

-

PRONOUNCE

degarelix (Firmagon)

Ferring Pharmaceuticals

3

Clinicaltrials.gov

-

 

PARP Inhibitors

This class of drugs is a type of targeted therapy that inhibits a tumor cell’s ability to repair itself, causing them to die. The patients with tumors that have evidence of genetic mutations are most likely to benefit from PARP Inhibitor treatment. 
 

Study Name

Drug

Sponsor

Phase

Clinical Trials Link

PHEN Link

QUEST

Niraparib,

Janssen R&D

2

Clinicaltrials.gov

PHEN Information

TALAPRO-1

talazoparib

Pfizer

2

Clinicaltrials.gov

PHEN Information

TRITON3

rucaparib (Rubraca)

Clovis Oncology

3

Clinicaltrials.gov

PHEN Information

Galahad

niraparib (Zejula)

Janssen R&D

2

Clinicaltrials.gov

PHEN Information

IMANOL

olaparib (Lynparza)

Spanish Oncology Genito-Urinary Group

2

Clinicaltrials.gov

-

Study of Olaparib Maintenance Following Cabazitaxel-Carbo in Men With AVPC

olaparib (Lynparza)

M.D Anderson Cancer Center

2

Clinicaltrials.gov

-

Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

olaparib (Lynparza)

Northwestern University

2

Clinicaltrials.gov

-

Olaparib for BRCAness Phenotype in Pancreatic Cancer

olaparib (Lynparza)

AstraZeneca

2

Clinicaltrials.gov

-


Monoclonal Antibodies

These drugs work by blocking a variety of signals in the body that help to destroy cancer cells or inhibit their ability to grow. 
 

Study Name

Drug

Sponsor

Phase

Clinical Trials Link

PHEN Link

CheckMate 650

 

nivolumab (Opdivo)

Bristol-Myers Squibb

2

Clinicaltrials.gov

-


Immunotherapy

This class of drugs stimulates the body’s own immune system to respond to cancerous cells. 
 

Study Name

Drug

Sponsor

Phase

Clinical Trials Link

PHEN Link

PrTK03

AdV-tk (ProstAtak)

Advantagene, Inc

3

Clinicaltrials.gov

-

Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 160 in Subjects With mCRPC

 AMG 160

Amgen

1

Clinicaltrials.gov

-

A Phase I/II, Safety Clinical Trial of DCVAC/PCa and ONCOS-102 in Men With Metastatic Castration-resistant Prostate Cancer

 

DCVAC/PCa, ONCOS-102

Sotio a.s.

2

Clinicaltrials.gov

 

KEYNOTE-921

pembrolizumab (Keytruda) plus Docetaxel

Merck

3

Clinicaltrials.gov

PHEN Information

KEYLYNK-010

pembrolizumab (Keytruda) plus Olaparib

Merck

3

Clinicaltrials.gov

PHEN Information

KEYNOTE-641

Pembrolizumab (Keytruda) plus enzalutamide

Merck

 

Clinicaltrials.gov

PHEN Information

Molecular Inhibitors

This class of drugs interferes with certain cell signals that prevent tumors from growing and helps facilitate the death of cancer cells. 
 

Study Name

Drug

Sponsor

Phase

Clinical Trials Link

PHEN Link

A Phase 2 Study of PCM-075 in Combination With Abiraterone and Prednisone

PCM-075

Trovagene, Inc.

2

Clinicaltrials.gov

-

ProSTAR

CPI-1205

Constellation Pharmaceuticals

2

Clinicaltrials.gov

-

Enzalutamide With and Without Ribociclib for Metastatic, Castrate-Resistant, Chemotherapy-Naive Prostate Cancer That Retains RB Expression

ribociclib (Kisqali)

Sidney Kimmel Cancer Center at Thomas Jefferson University

2

Clinicaltrials.gov

-

 

Chemotherapy

This class of drugs specifically interacts with cancer cells in a way that prevents them from multiplying and promotes cell death. 

 

Multiple Drug Interventions

The trials below have multiple drug mechanisms working to battle cancer in different ways. 
 

Study Name

Drugs

Sponsor

Phase

Clinical Trials Link

PHEN Link

Prostate Cancer Intensive, Non-Cross Reactive Therapy (PRINT) for Castration Resistant Prostate Cancer

abiraterone, prednisone, Radium-223 dichloride, cabazitaxel, carboplatin, enzalutamide

Icahn School of Medicine at Mount Sinai

2

Clinicaltrials.gov

-

PEACE2

cabazitaxel, Pelvic radiotherapy, ADT

Unicancer

3

Clinicaltrials.gov

-

A Trial of Androgen Deprivation, Docetaxel, and Enzalutamide for Metastatic Prostate Cancer

ADT+docetaxel+enzalutamide

Earle Burgess

2

Clinicaltrials.gov

-

Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors

avelumab (Bavencio) + talazoparib

Pfizer

2

Clinicaltrials.gov

-

Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

cabozantinib + atezolizumab

Exelis

2

Clinicaltrials.gov

-

 

  







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