Tall, Obese Men More Likely to Have Aggressive Prostate Cancer

(HealthDay News) — The larger a man, the greater his risk of developing and dying from aggressive prostate cancer, according to a study published online in BMC Medicine.

Aurora Perez-Cornago, PhD, a nutritional epidemiologist with the University of Oxford in the United Kingdom, and colleagues came to their conclusions based on data from 141,896 men in 8 European countries who participated in a large-scale study
of cancer and nutrition. Among these men, 7024 developed prostate cancer during an average 14 years of follow-up, including 726 diagnosed with high-grade cancer and 1388 with advanced-stage cancer. Of those diagnosed, 934 died from their cancer.

Every additional 4 inches of height was associated with a 21% increase in risk of being diagnosed with high-grade prostate cancer, and a 17% increased risk of dying from prostate cancer, the researchers found. The same held true regarding the size of a man's waist. Every 4-inch increase in waist circumference was associated with a 13% increased risk of developing high-grade prostate cancer and an 18% increased risk of dying from prostate cancer.

"In summary, the findings from this large European prospective study provide evidence that men with greater height and adiposity (high body mass index and waist circumference) have an elevated risk of high-grade prostate cancer and prostate cancer death," the authors write. "The data presented illustrate the complex association of adiposity and prostate cancer, which varies by disease aggressiveness."

Reference


1. Perez-Cornago A, Appleby PN, Pischon T, et al. Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study. BMC Med. 13 July 2017. doi: 10.1186/s12916-017-0876-7

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